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Dover Systems, in collaboration with the Church Laboratory of Harvard Medical School, introduces the Polonator G.007, a revolutionary approach to second-generation sequencing. The Polonator G.007 is a completely open platform, combining a high performance instrument at a very low price point, with freely downloadable, open-source software and protocols, low-cost, off-the-shelf reagents, and inexpensive flow cells. Together, the Polonator G.007 dramatically lowers both the upfront and recurring costs of entry to second-generation sequencing, while providing a robust, modular system that delivers exceptional throughput, accuracy, and reliability. Users may choose to use the standard protocols, reagents, and software as is, but are also totally free to innovate; all aspects of the system are open and programmable, providing the flexibility to support a wide range of alternative sequencing methods.